Yamaha makes two 300 HP motors currently (unless they discontinued the SWS HPDI). Anyway, they make / made a 300 2 stroke HPDI, likely the worst motor Yamaha has ever produced and the F300/F350 which appear to run well.
The problems with the HPDI 250/300 are well documented, not sure if they were ever resolved, the Fours are running strong and long so I think Yami is banking heavily on four stroke technology.
So the other choice would be 300 or 350 Four stroke. Yamaha and many boat builders have invested heavily and are counting on this design to perform. F300 is a "detuned" F350. If you are woried about weight, go for more power. Makes sense, right ? If you want a big single engine go for the F350.
Speaking of weight, the 2520 DV hull can easily handle the weight, twin F150 are popular and weigh about the same as a F300 or F350.
The boat actually benefits from weight aft, such as improved running attitude and better drainage at rest, downside if you have notch is more water over the back, but not that bad and not nearly as bad as MANY other boats I've been on.
Don't be afraid of the weight, but do be aware. The boat was built to handle weight of twins from the get go so the big single is easily accomodated.
Now if you want more oommfff than F250 (which I own), consider twin F150, more top end, better ride, same economy , more weight (which is good, too a a point). On the other hand reliablility GAIN is marginal (F250 goes and goes and goes) and maintenance $ is increased nearly by factor of two.
Not sure what a single F350 is going for, likely a little less than twin F150, especially considering rigging, etc.
let us know how you make out ....