If the performance of the F350 was comparable to twin F150 I'd be a bit disappointed. I would expect more top end, 50 HP is 50 HP and one less lower unit normally translates into less drag, the engine weight(s) are just about the same. I would expect significantly more top end, or a lower , MORE economical cruise RPM. However ....
Whats somewhat odd about the F250 is that the fuel burn (in MPG) pretty much remains the same over a wide range of RPMS. Thus, when you push it pretty hard, you don't get penalized like a two stroke . WOT with my F250 still gets a respectable 1.8 MPG.
I've spoken ad nauseum about the F250, the F250 has all the balls, or more, of ANY Yami 250 ever built.
I also fish on a 2520 with twin F150's. Economy wise, the F250 and F150(s) are nearly identical. MPG is about 2.0 - 2.4 depending on load, etc. The twins run about 5 MPH faster, WOT and do stay on plane better under load and with a sea running.
These are real world numbers, on fully equiped boats.